Retinoic acid inhibits the angiogenesis of human embryonic stem cell-derived endothelial cells by activating fbp1-mediated gluconeogenesis

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  • who: Zhuangzhuang Yang from the Department of Cardiovascular Surgery of the First Affiliated Hospital Suzhou Medical College, Soochow University, Suzhou, China have published the article: Retinoic acid inhibits the angiogenesis of human embryonic stem cell-derived endothelial cells by activating FBP1-mediated gluconeogenesis, in the Journal: (JOURNAL)
  • what: The authors investigated the role of RA in hESC-ECs and found that RA reduced EC angiogenesis, as reflected by the reduced sprouting, migration, and proliferation capacities, through facilitating FBP1-driven gluconeogenesis and reducing glycolytic flux.
  • how: Collectively these results indicated that hESCECs are a . . .

     

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