Retromer deficiency in tauopathy models enhances the truncation and toxicity of tau

HIGHLIGHTS

• who: Jamshid Asadzadeh from the (UNIVERSITY) have published the article: Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau, in the Journal: (JOURNAL) of 10/08/2022
• what: The authors develop adult-onset models for human Tau (hTau) toxicity in Drosophila that enable age-dependent quantitative measurement of central nervous system synapse loss and axonal degeneration, in addition to effects upon lifespan, to facilitate evaluation of factors that may contribute to Tau-dependent neurodegeneration. The authors show using models for human Tau toxicity in Drosophila, and recapitulated in mammalian neurons, that reduction . . .
  

   

  

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