Retrospective study for the universal applicability of the residue-based linear free energy relationship in the two-state exchange of protein molecules

HIGHLIGHTS

SUMMARY

Interestingly, the authors discovered linear relationships in the log k vs. log K and log k′ vs. log K ­plots10,15. In contrast to the conventional LFERs, the data points (log K, log k) and_(log K, log k′) in the LFER are derived from different positions in one polypeptide chain. The two axes are not independent due to the equation, K=k/k′, i.e., log K=log k - log k′, which could generate an artificial linear relationship in the REFER plot (see the next section). Since either log k or log k . . .

 



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