HIGHLIGHTS
SUMMARY
With a contiguous spread of the disease process in the motor neuron network resulting in progressive motor weakness. Reverse_transcriptase activity has been found consistently in these individuals even before the term, "reverse_transcriptase" was coined. Non-LTR retrotransposons have open_reading_frames (ORFs), including ORF2 which encodes reverse_transcriptase and endonuclease for transposition and are flanked by untranslated regions (UTRs). In 1975, Viola et_al reported high levels of RNA-instructed DNA_polymerase/reverse_transcriptase activity in extracts from the brains of two individuals with ALS and brain tissue from an asymptomatic patient from the island of Guam but not from . . .
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