Rev7 has a dynamic adaptor region to accommodate small gtpase ran/shigella ipab ligands, and its activity is regulated by the rangtp/gdp switch

HIGHLIGHTS

• who: Xin Wang from the (UNIVERSITY) have published the research work: REV7 has a dynamic adaptor region to accommodate small GTPase RAN/Shigella IpaB ligands, and its activity is regulated by the RanGTP/GDP switch, in the Journal: (JOURNAL) of July/12,/2019
• what: As the small GTPase Ras-associated nuclear protein (RAN) is a potential upstream regulator of REV7, the authors focused on structural study of the REV7-RAN interaction. Based on the findings , the authors propose a model where REV7 preferentially binds to the RAN-GTP conformation (Fig 6).
• how: To . . .
  

   

  

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