HIGHLIGHTS
SUMMARY
The chemokine (C-C motif) ligand 28 (CCL28) acts as a protective factor after SCI by recruiting C-C chemokine receptor 10 (CCR10)-positive and immunosuppressive regulatory T_cells (Wang et_al, 2019). Chronic SCI can impair CD8 T_cell function by up-regulating programmed cell death-1 expression (Zha et_al, 2014). γδ T_cells are recruited to the SCI site, promoting the inflammatory response and exacerbating neurological impairment. CCL2/ CCR2 signaling is critical for T_cell recruitment to the SCI site and may be used as a novel therapeutic target in the future (Xu P. et_al, 2021). As previously . . .
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