HIGHLIGHTS
SUMMARY
Dysregulation of mucin domain expression and aberrant mucin domain glycosylation patterns have been implicated in disease pathologies, especially in tumor progression, where mucins modulate immune_responses and also promote proliferation through biomechanical mechanisms13-15. Instead of the more traditional categorization of the glycoproteome into Nand O-glycoproteins (both of which are represented by mucindomain glycoproteins), it is logical to parse the glycoproteome into the mucinome, a family of glycoproteins whose mucin domains make them functionally related. This gives StcE both the selectivity needed to specifically bind mucin domains and the breadth to bind diverse mucin . . .
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