HIGHLIGHTS
- who: Miriam Butler from the Ghent University, Belgium United States have published the paper: Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways, in the Journal: (JOURNAL)
- what: The authors showed that IKZF1-mediated regulation of AKT and ERK signaling contributes to GC resistance in BCPALL.
- how: The authors explored the connection between loss of IKZF1 function AKT signaling and GC therapy resistance using an isogenic cell line model normal B cells derived from Ikzf1+/- mice as well patient-derived ALL xenografts. The following plasmids were obtained . . .
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