HIGHLIGHTS
- who: Tamara S. Rodems from the University of Briefly, DNA was digested with AluI and HhaI restriction enzymes (New England have published the paper: Reversible epigenetic alterations regulate class I HLA loss in prostate cancer, in the Journal: (JOURNAL) of 15/08/2022
- what: In this report the authors demonstrate that transcriptional downregulation of is coordinated by silencing mechanisms which can be reversed to functionally re-express and restore MHC-I-dependent T-cell activation. The authors show that methylation in the genes can be detected in prostate cancer circulating tumor cells (CTCs) with low . . .
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