Review of lung particle overload, rat lung cancer, and the conclusions of the edinburgh expert panel—it’s time to revisit cancer hazard classifications for titanium dioxide and carbon black

HIGHLIGHTS

  • who: Kevin E. Driscoll from the Laboratoire National de Santé University Hospital of Cologne, Germany have published the research: Review of Lung Particle Overload, Rat Lung Cancer, and the Conclusions of the Edinburgh Expert Panel—It's Time to Revisit Cancer Hazard Classifications for Titanium Dioxide and Carbon Black, in the Journal: (JOURNAL)

SUMMARY

    Rat lung cancer after inhalation of poorly soluble low toxicity particles occurs only under exposure conditions which overload macrophage-mediated particle clearance i.e., cause lung particle overload.. A consequence of overloading clearance is a build-up of particulate . . .

     

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