HIGHLIGHTS
SUMMARY
Externally, the glial activation and immune_response onset make the microenvironment intractable, thereby suppressing tissue repair and axon regrowth (Bo-Yin et_al, 2021). Recent studies have demonstrated that astrocytes can mediate the T_cell`s polarization after CNS injury. Under the CNS injury condition, the astrocyte-oriented cytokine enrichment in the lesion induces the astrocyte-associated CD4+ T_cells migration and polarization, frontiersin.org TABLE 1 SCI immunomodulation-associated cell types and roles. The IFN-γ can be presented to CD8+ T_cells and induced the cytotoxicity reaction of CD8+ T_cells toward OPC (Kirby et_al, 2019).. Secretion: Cytokines, antibodys . . .
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