HIGHLIGHTS
- who: Marlies C. Ludikhuize from the University Medical Oncology, CS Utrecht, The Netherlands have published the paper: Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRASG12D glycolytic colorectal tumors, in the Journal: (JOURNAL) of 26/Nov/2021
- what: The authors show that p53-deficiency consistently provokes DNA damage and cell death upon treatment both in TPOs and PDOs. This model has been studied in vitro and in vivo and APK and APKS organoids recapitulate morphological features of respectively adenocarcinoma and poorly differentiated adenocarcinoma with metastatic potential37 38. The authors show that when applied . . .
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