Rgd-containing peptides inhibit fibrinogen binding to platelet αiibβ3 by inducing an allosteric change in the amino-terminal portion of αiib*

HIGHLIGHTS

• who: Ramesh B. Basani from the (UNIVERSITY) have published the paper: RGD-containing Peptides Inhibit Fibrinogen Binding to Platelet αIIbβ3 by Inducing an Allosteric Change in the Amino-terminal Portion of αIIb*, in the Journal: (JOURNAL) of December/20,/2000

SUMMARY

Ligands appear to bind to ␣IIb␤3 by interacting with the amino-terminal portion of ␤3, although the specific residues involved are not known. A region of ␤3 encoded by the fourth and fifth exons of the ␤3 gene that encompasses amino_acids 95-223 has been implicated in ligand binding. Chemical . . .

 



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