Rho gtpase signaling in platelet regulation and implication for antiplatelet therapies

HIGHLIGHTS

  • who: Akhila Dandamudi and collaborators from the Division of Experimental Hematology and Cancer Biology, Cincinnati Children`s Hospital Medical Center, Burnet Cincinnati, OH, USA Department of Pathology, University of Cincinnati Graduate School, Cincinnati, OH, USA have published the Article: Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies, in the Journal: (JOURNAL)
  • what: In contrast to the findings of the Pf4-Cre Cdc42fl/fl study, this study showed that Cdc42-/platelets exhibited diminished phosphorylation of PAK1/2, inhibition of filopodia formation on immobilized CRP or fibrinogen, inhibition of CRP- or thrombin-induced platelet . . .

     

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