Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

HIGHLIGHTS

• who: Ahmad Sharanek from the France Rennes , University have published the research: Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs, in the Journal: Scientific Reports Scientific Reports
• what: By performing a comparative analysis of the 6 compounds, the study showed that BC could be deformed early depending on the tested compounds. This work provides the first evidence that the ROCK/MLCK pathway and its associated enzymes are major targets of the cholestatic compounds that lead to deformation of the apical lumen . . .
  

   

  

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