Ribosome impairment regulates intestinal stem cell identity via zakɏ activation

HIGHLIGHTS

• who: Joana Silva from the Ethical approval All experiments were carried out with the approval of the relevant ethical bodies: NKI Animal Welfare Body, University of Copenhagen Institutional Animal Care and Use Committee, and the NKI-AVL Institutional Review Board (IRB) have published the research: Ribosome impairment regulates intestinal stem cell identity via ZAKɏ activation, in the Journal: (JOURNAL) of 18/08/2021
• what: Using intestinal organoids and mouse models, the authors show that upon ribosome impairment (driven by Rptor deletion, amino_acid starvation, or low dose cyclohexamide treatment) ISCs gain an Lgr5-negative, fetal-like . . .
  

   

  

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