Riok3 and its alternatively spliced isoform have disparate roles in the innate immune response to rift valley fever virus (mp12) infection

HIGHLIGHTS

• who: Thomas C. Bisom and colleagues from the Department of Chemistry and Biochemistry, University of Montana, Missoula, MT, USA have published the paper: RIOK3 and Its Alternatively Spliced Isoform Have Disparate Roles in the Innate Immune Response to Rift Valley Fever Virus (MP12) Infection, in the Journal: Viruses 2022, 2064 of /2022/
• what: The authors demonstrate that RIOK3 is required for mounting an IFN response but negatively regulates the NFu03baB-mediated inflammatory response, and intriguingly, alternative splicing of RIOK3 reverses these effects.

SUMMARY

10.3390/v14092064 When RNA viruses are detected . . .

 



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