Rip140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating glut3 expression through transcriptional crosstalk between hypoxia induced factor and p53

HIGHLIGHTS

  • who: Valentin Jacquier from the IRCM, Institut de Recherche en Cancu00e9rologie de Montpellier, INSERM, University of Montpellier, ICM, Montpellier, France have published the research: RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53, in the Journal: (JOURNAL)
  • how: Using a luciferase reporter assay the authors showed that increasing doses of p53 inhibited the luciferase activity driven by the GLUT3 promoter (Fig 5a) and that RIP140 reinforced this inhibition (Fig 5b).
  • future: Whether there is a ternary complex or if the . . .

     

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