HIGHLIGHTS
- who: Hongyan Guo et al. from the Viral Immunology Center, Department of Biology, Georgia State University, Atlanta, Georgia, United States have published the Article: RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis, in the Journal: (JOURNAL) of September/19,/2022
- what: The authors show for the first time that RIPK3-mediated necroptosis contributes to restricting HSV1 replication in corneal tissues, but, in the brain, a kinase-independent function of RIPK3 contributes to restricting HSV1 replication that is dependent on caspase 8. The authors show that HSV1-induced RIPK3-dependent necroptosis appears to operate . . .
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