Rna-seq of dermal fibroblasts from patients with hypermobile ehlers-danlos syndrome and hypermobility spectrum disorders supports their categorization as a single entity with involvement of extracellular matrix degrading and proinflammatory pathomechanisms

HIGHLIGHTS

• who: Marco Ritelli et al. from the Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy have published the research work: RNA-Seq of Dermal Fibroblasts from Patients with Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders Supports Their Categorization as a Single Entity with Involvement of Extracellular Matrix Degrading and Proinflammatory Pathomechanisms, in the Journal: Cells 2022, 11, 4040. of 12/Dec/2022
• what: The authors propose a disease model in which an unbalanced ECM remodeling triggers a vicious cycle with a synergistic contribution of ECM degradation . . .
  

   

  

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