HIGHLIGHTS
SUMMARY
The authors generalised the model by applying it Identifying biomarkers that can be used in clinical routine to diagnose patients, monitor disease and response to treatment is required for more precision-based medicine (Mayeux, 2004; Chase Huizar et_al, 2020). Combinations of mRNAs can have high diagnostic efficacy in multiple diseases (Gustafsson et_al, 2014; Mao et_al, 2018; Gawel et_al, 2019; Cha et_al, 2020). Ideally, mRNA profiling of clinical samples could be used to identify protein biomarkers for diagnoses, subtyping of diseases and evaluating treatment response. mRNA expression has often been used to determine corresponding protein . . .
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