HIGHLIGHTS
- who: Adam E. Hall from the Institute The University have published the article: RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors aimed to identify universal therapeutic targets for CRC by determining the mechanisms important for cancer cell growth. As therapeutic targeting does not lead to target inhibition equivalent to genetic knockout the authors aimed to phenocopy clinical intervention more accurately using doxycycline-inducible short hairpin RNA (shRNA) expression.
- how: The authors identified widespread dysregulation . . .
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