Rnase h2, mutated in aicardi⠀goutières syndrome, resolves co-transcriptional r-loops to prevent dna breaks and inflammation

HIGHLIGHTS

• who: Agnese Cristini from the University of Oxford, South Parks Road, Oxford , RE, UK have published the Article: RNase H2, mutated in Aicardiu2800Goutiu00e8res syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that RNase H2 plays a role in the resolution of co-transcriptional R-loops in human cells. By defining the function of RNase H2 in R-loop metabolism, the work provides insight into how R-loop balance is maintained at physiological levels in human cells and how its dysregulation . . .
  

   

  

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