Rnf185 regulates proteostasis in ebolavirus infection by crosstalk between the calnexin cycle, erad, and reticulophagy

HIGHLIGHTS

• who: Jing Zhang from the (UNIVERSITY) have published the article: RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy, in the Journal: (JOURNAL) of 30/09/2022
• what: The authors show that calnexin and calreticulin trigger Zaire Ebolavirus (EBOV) glycoprotein GP1,2 misfolding. Based on these observations, the authors propose that the CANX-RETREG1 axis plays a role in EBOV-GP1,2 downregulation (Fig 10).
• how: Nature Communications | 136007 RNF26 decreases EBOV-GP12 expression in an E3 ubiquitin ligase activity-independent manner the results showed that SQSTM1 . . .
  

   

  

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