Robust cox-2-mediated prostaglandin response may drive arthralgia and bone destruction in patients with chronic inflammation post-chikungunya

HIGHLIGHTS

  • who: Yosra Bedoui and colleagues from the France Editor: VAguilar, University of Texas have published the research: Robust COX-2-mediated prostaglandin response may drive arthralgia and bone destruction in patients with chronic inflammation post-chikungunya, in the Journal: (JOURNAL) of February/17,/2021
  • what: The authors aimed to investigate the capacity of CHIKV and MTX to modulate the expression of the PGE2-degrading enzyme 15-PGDH in HSF. mRNA levels of 15-PGDH were assessed by qRT-PCR at 6h and 24h after CHIKV or PIC exposure in the presence or absence of MTX . . .

     

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