HIGHLIGHTS
- who: Zhanna Alekseenko from the Karolinska Institute Lund University have published the research work: Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 11/05/2022
- what: The authors show that a 48-hour RA pulse in combination with SHH pathway activation promote a rapid specification of LMX1A+/FOXA2+/OTX2+ vMB progenitors that differentiate into functional mDA neurons at high yield in_vitro, and which engraft and restore motor deficits after transplantation into a rat model of PD. The authors show . . .
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