HIGHLIGHTS
- who: Amparo Romero from the (UNIVERSITY) have published the paper: Role of a Pro-sequence in the Secretory Pathway of Prothyrotropin-releasing Hormone*, in the Journal: (JOURNAL) of November/14,/2008
- what: The authors have demonstrated by mutational studies that an N-terminal proregion preproTRH(25-50) located after the signal sequence contains critical structural information to ensure the right intracellular transport of proTRH precursor from ER to Golgi compartment. The authors focus on early precursor maturation. This study provides evidence that a proregion in proTRH prohormone plays a important structural role determining the conformational . . .
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