Role of cdh23 as a prognostic biomarker and its relationship with immune infiltration in acute myeloid leukemia

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SUMMARY

    The downregulation of CDH23 expression was significantly association with poorer outcome in patients with diffuse large B cell lymphoma. The authors investigated the expression profile and biological functions of CDH23 in AML and further analyzed the association between CDH23 expression and the AML tumor immune microenvironment using systematic bioinformatics analysis. The authors utilized the "Single Gene Analysis" module to perform a differential mRNA expression and prognostic analyses of CDH23 expression in AML patients and healthy donors. Subsequently, the authors used several computational algorithms to estimate the abundance of various TIICs (B cells, ­CD4+T_cells . . .

     

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