HIGHLIGHTS
- who: Mithalesh K. Singh from the DepartmentUniversity of have published the research: Role of dual specificity phosphatases (DUSPs) in melanoma cellular plasticity and drug resistance, in the Journal: Scientific Reports Scientific Reports
- what: The authors focused on DUSPs genes with a probability of differential expression of at least 0.99. The study shows a relationship between DUSPs, MAPKi-resistance and neuronal differentiation of melanoma, and suggest that targeting DUSPs is a potential strategy to overcome MAPKi-resistance in melanoma.
- how: Query of TCGA melanoma dataset showed that high DUSP1 mRNA expression is associated . . .
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