Role of fc core fucosylation in the effector function of igg1 antibodies

HIGHLIGHTS

  • who: Josu00e9e Golay from the Karolinska Institutet (KI), Sweden Lund University, Sweden have published the paper: Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies, in the Journal: (JOURNAL)

SUMMARY

    IgGs are among the most abundant proteins in the circulation (700-1600 mg/dl in healthy adults), and specific IgGs are induced in response to infection, endogenous or allogeneic challenges, or by vaccination. Therapeutic monoclonal_antibodies (mAbs) have emerged as an important therapeutic option in cancer since the approval in 1997 of the anti-CD20 antibody rituximab for the treatment of . . .

     

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