HIGHLIGHTS
- who: M. Tariq Khan from the MTariq Khan and Suresh K. Joseph, From the Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania , Previous studies have shown that small interfering RNA knockdown and pharmacological inhibition of inositol, , trisphosphate receptors (IP Rs) stimulate autophagy. We have investigated autophagy in chicken , cell lines containing targeted deletions of all three IP R isoforms (triple knock-out (TKO) cells). Using gel shifts of microtubule-associated protein , light chain , as a marker of autophagy, we find that TKO cells have enhanced basal autophagic flux even under nutrient . . .
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