HIGHLIGHTS
SUMMARY
Multiple_sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system, characterised by focal lesions of primary demyelination and neurodegeneration. In recent decades, several observational studies worldwide showed an inverse association between vitamin D levels 2 of 8 and MS risk. Vitamin D levels are influenced by both environmental and genetic factors. Accordingly, the potential role of single nucleotide polymorphisms (SNPs) in genes codifying molecules involved in vitamin D metabolism in MS susceptibility has also been evaluated, achieving contrasting results. In this observational study, the authors evaluated the potential association among vitamin . . .
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