Role of non-specific interactions in the phase-separation and maturation of macromolecules

HIGHLIGHTS

  • who: Rakesh Krishnan and colleagues from the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India have published the paper: Role of non-specific interactions in the phase-separation and maturation of macromolecules, in the Journal: (JOURNAL)
  • what: This model has been effectively employed to study phase separating proteins, and how the valency of stickers (specific interactions) affect the phase separation and aggregation . Using a coarse-grained representation of proteins, the authors explore various parameters -specific interaction strengths, non-specific interaction strengths, the ratio of non-specific to specific interaction sites, and . . .

     

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