HIGHLIGHTS
SUMMARY
PARPi have demonstrated to control the tumor immune microenvironment (TME) by modulating both cancer cell genomic instability and T_cell mediated responses. The authors have investigated additional unexplored mechanisms potentially elicited by PARP-1 inhibition that could provide support to the T_cell stimulation induced by ICIs, along with their intrinsic limitations. The influence of PARPi on anti-tumor T_cell immune_response and on TME features can be mediated by different mechanisms. Other released proteins include C-X-C motif chemokine ligand (CXCL)1, CXCL2, CXCL9, and CXCL10 that support both development and tumor infiltration of macrophages . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.