Role of protein kinase c δ in er stress and apoptosis induced by oxidized ldl in human vascular smooth muscle cells

HIGHLIGHTS

• who: P Larroque-Cardoso from the Department University of Colorado Denver, Aurora, CO, USA have published the research work: Role of protein kinase C u03b4 in ER stress and apoptosis induced by oxidized LDL in human vascular smooth muscle cells, in the Journal: (JOURNAL)
• what: The authors report for the first time that PKCd is activated by oxLDL in human VSMC and contributes to oxLDL-induced ER stress-dependent apoptotic signaling through the I IRE1a/JNK pathway. The authors provided evidence that the rise in intracellular ROS triggered the phosphorylation of the tyrosine 311 residue . . .
  

   

  

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