HIGHLIGHTS
- who: Nicolas Mandel and Nitin Agarwal from the Institute of Pharmacology, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany have published the research work: Role of SUMOylation in Neurodegenerative Diseases, in the Journal: Cells 2022, 11, 3395. of /2022/
- how: Similar observations were made in transgenic mice expressing His-tagged SUMO2 . Patient data showed that 40-50 repeats cause the onset of disease in adults whereas 50-120 repeats lead to juvenile HD .
- future: Although a more detailed analysis is required atindifferent levels disease progresoxidative stress impaired the SUMOylation-mediated cellular protective mechanism sion . . .
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