Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach

HIGHLIGHTS

• What: The authors aimed to establish a novel, translational model in which the authors could directly interrogate the influence of the circulating milieu of mice and humans in age-related arterial function. For the validation of the models, existing data from seven young and seven old male mice were used to compare the effects of age-matched mouse serum exposure on six young and eight old male mice (i.e., young mouse arteries exposed to young mouse serum and old mouse arteries exposed to old mouse serum) (Fig 1, green). In Vivo Aortic Stiffness To establish that . . .
  

   

  

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