Role of the degree of oligomerization in the structure and function of human surfactant protein a*

HIGHLIGHTS

• who: Fernando Sa̕nchez-Barbero from the pratrimeric assembly was essential for Ca2⫹-dependent SP-A self-association, SP-A-induced aggregation of phospholipid vesicles and LPS micelles, and SP-A-promoted adsorption of SPB/SP-C-surfactant membranes to an air-liquid interfaceHowever, supratrimeric assembly was not essential for the role of SP-A in the inhibition of rough or smooth LPS inflammatory response, which likely involves SP-A binding to cellular receptors by its globular and/or neck domains (9, ). Acknowledgments-We acknowledge Dr. F. U. Bosch from ALTANA Pharma for strong advice and support . . .
  

   

  

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