Role of the n-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice*

HIGHLIGHTS

• who: Sebastien Fuchs from the screened for targeted homologous recombination using a strategy of polymerase chain reaction (PCR) and genomic Southern blot analysisChimeric, heterozygote, and homozygous mutant mice were generated as previously described (12, ). All studies were performed on , generation litters generated from the breeding of , heterozygous animals and on some animals obtained by breeding , homozygous ACE., mice with heterozygous ACE knock-out mice (ACE.1) (12). Age- and gender-matched littermate controls were used in all studies. Animal procedures were approved by the Institutional Animal Care and Use Committee and were supervised by the Emory University . . .
  

   

  

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