Roles of pi3kγ and pi3kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the pi3kγ/δ inhibitor duvelisib

HIGHLIGHTS

• who: Kathleen J. Till from the DepartmentUniversity of have published the article: Roles of PI3Ku03b3 and PI3Ku03b4 in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Ku03b3/u03b4 inhibitor duvelisib, in the Journal: Scientific Reports Scientific Reports
• what: The authors show that PI3Ku03b3 is expressed by MCL cells and impacts multiple points of the disease process that are important for disease progression (Fig 5).
• how: The data is in line with the fact that inhibition of mTOR and AKT downstream targets of PI3K have been shown to result in decreased . . .
  

   

  

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