Roles of tgf-1 in viral infection during pregnancy: research update and perspectives

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SUMMARY

    The placenta has an indispensable role as a barrier to protect the fetus from any possible vertical infections from the mother, addressing a balance between the tolerance of an allogeneic fetus and the protection against pathogens naturally established at the maternal-fetal interface in a healthy pregnancy. Viral infection during pregnancy can result in congenital viral syndromes such as congenital rubella syndrome (CRS) or congenital Zika syndrome (CZS), particularly in the first trimester. CRS can occur throughout the pregnancy; however, 90% of the cases of CRS were reported as a result of a rubella . . .

     

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