Room-temperature crystallography reveals altered binding of small-molecule fragments to ptp1b

HIGHLIGHTS

• who: Tamar (Skaist) Mehlman et al. from the Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA , Diamond Light Source, Didcot, United Kingdom Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK have published the paper: Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B, in the Preprint: biorxiv of 02/Nov/2022
• what: The authors show that at RT fewer ligands bind and often more weakly -- but with a variety of temperature-dependent differences including unique binding poses changes in solvation new binding sites and distinct . . .
  

   

  

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