Room temperature reduction of titanium tetrachloride-activated nitriles to primary amines with ammonia-borane

HIGHLIGHTS

• who: P. Veeraraghavan Ramachandran and Abdulkhaliq A. Alawaed from the Department of Chemistry, Purdue University, Oval Drive, West Lafayette, IN Department of Chemistry, Purdue University, Oval Drive, West Lafayette, IN, USA have published the research work: Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane, in the Journal: (JOURNAL) of 16/Dec/2022
• what: We have developed a simple protocol for the reduction of nitriles to afford primary amines using ammonia-borane as the reductant in the presence of one molar equivalent of TiCl4 in diethyl ether at room temperature . . .
  

   

  

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