Routes of ca2+ shuttling during ca2+ oscillations

HIGHLIGHTS

• who: László Pecze from the László Pecze1, Walter Blum, and Beat Schwaller From Anatomy, Department of Medicine, University of Fribourg, Route Albert-Gockel, Fribourg, Switzerland Background: Ca2⫹ oscillations in mesothelial cells depend on Ca2⫹ influxResults: However, the "lanthanum insulation method" renders the oscillations independent of extracellular Ca2⫹. Conclusions: Multiple pathways of Ca2⫹ shuttling are operating simultaneously during Ca2⫹ oscillations. Significance: Experimental and mathematical approaches shed light on the mechanism of Ca2⫹ oscillations. In some cell types, Ca2ⴙ oscillations are strictly dependent on Ca2ⴙ influx across the plasma membrane, whereas in others, oscillations also persist in . . .
  

   

  

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