HIGHLIGHTS
- who: Yeon Ja Choi and collaborators from the Editor:, University of Bradford have published the Article: RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis, in the Journal: (JOURNAL)
- what: The authors report that RPGRIP1L is also involved in the maintenance of desmosomal junctions between keratinocytes. Loss of RPGRIP1L induces internalization of the desmogleins Because disrupting Rpgrip1l resulted in consistent changes in the desmogleins under both in_vivo and in_vitro conditions, and the blistering phenotype observed in Rpgrip1l-/-skins is similar to what is seen in pemphigus, a severe blistering disorder caused primarily . . .
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