Rrm adjacent tardbp mutations disrupt rna binding and enhance tdp-43 proteinopathy

HIGHLIGHTS

• who: Abbreviations ALS = amyotrophic and collaborators from the (UNIVERSITY) have published the research work: RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy, in the Journal: (JOURNAL)
• what: The authors report a novel FTD/ALS-linked mutation, K181E, which causes catastrophic disruption in TDP-43 protein-RNA binding. Investigating the impact of loss of RNA-binding on TDP43 proteinopathy further, the authors demonstrate that mutations that leave TDP-43 incapable of binding RNA promote the accumulation of insoluble aggregates in the nucleus and cytoplasm, suggesting the loss of interaction with RNA can . . .
  

   

  

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