HIGHLIGHTS
- What: The authors generated whole-body Rufy4 knockout mice to determine the role of RUFY4 in osteoclastogenesis. The study showed that although Rufy4 was specifically upregulated by RANKL stimulation, all other Rufy family members were also slightly induced, regardless of whether Rufy4 was deleted (Fig S1c and Fig S3e), suggesting that other RUFY proteins besides RUFY4 may also contribute to osteoclastogenesis.
- Who: Minhee Kim from the Constructs Full-length Rufy, cDNA (NM_0011706411) was amplified from osteoclasts. After PCR amplification, Rufy, and its deletion mutants were subcloned into p3xFlag-, (Addgene)., xFlag-tagged , and its mutants were . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.