Running title: cancer therapy by combination of oligonucleotides academy section: cellular

HIGHLIGHTS

  • who: Telomerase and colleagues from the Centromere/kinetochore complex is the area in that DNA combines with centromere proteins, which are required to stabilize the intact microtubes in bi-orientation chromosomes (Song et_al, Okada et_al, )Centromere protein B (CENP-B) is , kD constitutive protein that passes in the inner domain of Centromere/ Kinetochore complex by binding with , bp CENP-B box in α-satellite DNA (Song et_al, ). However, CENP-B is highly expressed during cancer cell proliferation, and its downregulation leads to a reduction in the cancer DNA replication activity and, consequently, cancer cell death (Song et_al, ), the . . .

     

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