Runx1-eto and runx1-evi1 differentially reprogram the chromatin landscape in t(8;21) and t(3;21) aml

HIGHLIGHTS

• who: Justin Loke from the College University of Birmingham, TT Birmingham, UK have published the research: RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML, in the Journal: (JOURNAL) of May/23,/2017
• what: For t(8;21) cells, this analysis showed that RUNX1 and RUNX1-ETO sites cluster separately with a strong enrichment of RUNX, C/EBP, and GFI1B motifs for both RUNX1-ETO and RUNX1 peaks (boxed in blue), a selective enrichment of E-box motifs for RUNX1-ETO peaks, and a specific . . .
  

   

  

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