Ruthenium complexes show potent inhibition of akr1c1, akr1c2, and akr1c3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line

HIGHLIGHTS

• who: . and collaborators from the University of Strathclyde, United Kingdom have published the Article: Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line, in the Journal: (JOURNAL) of 19/03/2021
• what: One of the aims of this study was thus to get new insights in this important field of metallodrug design focusing on the inhibition of AKR1C enzymes that have roles in chemoresistance. The authors investigated the inhibitory action of a series of 10 organoruthenium complexes with β-diketonate and 8hydroxyquinolinate ligands. In . . .
  

   

  

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